While there's "no comment at this time," Deputy Attorney General James Cole hinted last month at what the Obama administration's response might be.
"Each case is going to rise and fall on its own unique facts," Cole said in a 60 Minutes interview. "Any of that is still in violation of the Controlled Substances Act of the federal law. We're not interested in bothering people who are sick and are using it in the recommendation of a doctor. We are concerned with people who are using it as a pretext to become large-scale drug dealers."
Colorado Gov. John Hickenlooper, an opponent of Amendment 64, had this to say late last night: "The voters have spoken and we have to respect their will. This will be a complicated process, but we intend to follow through. That said, federal law still says marijuana is an illegal drug so don't break out the Cheetos or gold fish too quickly."